Here are some of the well know buggy problems in Vista and a quick solution of the fixes.

AMD Cool & Quiet drivers won’t load - I guess this problem occurs if you have overclocked your PC. Don’t worry the fix is are already included inside the system.

iPod hard drive gets corrupted - This issue pops up with iTunes 7.1 when using safely remove device option in the tray. Its so simple, just unplug the device manually no remove dialog’s whatsoever

VPN doesn’t work - This affects people who remote log into their PC using VPN. This one gets fixed by updating Windows.

Adobe Reader won’t work - This problem occurs only when User Account Control(UAC) is turned off. To fix it just turn it on and re-install Adobe Reader, or installing in XP Compatibly Mode.

Firewire device won’t work - This usaully happens when Vista goes to sleep while the device is plugged in. It’s a mass storage driver issue (Sbp2Port.sys) that only needs to be updated.

For more on the fixes Extreme tech